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Pyridostatin TFA
CAS No. 1472611-44-1
Pyridostatin TFA ( —— )
产品货号. M18040 CAS No. 1472611-44-1
Pyridostatin Trifluacetate Salt 是一种 G-四链体稳定剂，在无细胞测定中 Kd 为 490 nM，靶向一系列原癌基因，包括 c-kit、K-ras 和 Bcl-2。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
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| 5MG | ￥599 | 有现货 |
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| 10MG | ￥915 | 有现货 |
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| 25MG | ￥1628 | 有现货 |
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| 50MG | ￥2471 | 有现货 |
|
| 100MG | ￥4155 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pyridostatin TFA
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pyridostatin Trifluacetate Salt 是一种 G-四链体稳定剂，在无细胞测定中 Kd 为 490 nM，靶向一系列原癌基因，包括 c-kit、K-ras 和 Bcl-2。
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产品描述Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
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体外实验Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin TFA is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin TFA causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin TFA induces the formation of DNA DSBs. Remarkably, Pyridostatin TFA (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level. Cell Viability Assay Cell Line:Over 60 different cancer cell linesConcentration:10 μMIncubation Time:48 hoursResult:Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.
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体内实验——
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同义词——
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通路Neuroscience
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靶点GluR
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受体G-quadruplexe
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研究领域Others-Field
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适应症——
化学信息
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CAS Number1472611-44-1
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分子量938.71
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分子式C37H35F9N8O11
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(Nc1cc(OCCN)c2ccccc2n1)c3cc(OCCN)cc(n3)C(=O)Nc4cc(OCCN)c5ccccc5n4.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7.
